Ref: #68388

Founding Full Stack Engineer

Founding AI Engineer – Oncology AI Platform (SF, In-Person)

Why This Role Is Unique

  • 🎯 High-impact, early seat – As hire #7, you'll help architect the intelligence behind a first-of-its-kind AI platform focused on transforming a deeply complex domain of healthcare. You’ll shape product and engineering culture from the ground up.

  • 📊 Unprecedented data advantage – We work with a proprietary dataset comprising 400M+ radiology, pathology, genomic, and clinical records from leading U.S. institutions.

  • 🤖 Frontier-model access – You'll work directly with some of the most advanced model architectures available today, including pre-release access to models from top AI labs, integrated into a highly specialized medical-AI framework.

  • 💰 Massive market, urgent mission – The opportunity sits at the intersection of a multi-trillion-dollar industry and a global health imperative. You'll have the technical canvas to make a significant dent in both.

  • 🧠 Elite, execution-driven team – Collaborate with accomplished founders (including a national champion athlete and ex-intelligence CTO), world-class engineers, and a board of top oncologists from institutions like Johns Hopkins, UCLA, and MSK.


What You’ll Build (First 3 Months)

  • Architect and deploy multi-agent AI workflows that synthesize structured and unstructured data to produce end-to-end treatment insights.

  • Own post-training pipelines for cutting-edge LLMs (LoRA, RLHF, RLAIF), tailoring frontier models with medical expertise.

  • Develop reward models focused on safety, factuality, and outcome-relevance in oncology.

  • Prototype temporality-aware embeddings to enable longitudinal reasoning across patient timelines.

  • Expand a bespoke evaluation system with synthetic vignettes, offline policy metrics, and adversarial probing.

  • Integrate deterministic tools and perception models into reasoning chains (e.g., calculators, image recognition, structured decision aids).

  • Build and refine retrieval and verification scaffolding, including KAG/RAG modules and factuality-checker agents.


Tough Problems You'll Tackle

  • Designing agentic planners that chain together reasoning trees across planning, execution, retrieval, and decision support.

  • Training reward models where signal is sparse, noisy, or contradictory.

  • Encoding real-world EHR timelines in a way that preserves nuance and disease progression over time.

  • Creating self-improving systems that turn system failures into new, high-quality training data—without relying on human labeling.


Who You Are

  • 2+ years of experience building from 0→1 with strong full-stack fluency (backend and frontend).

  • Comfortable in ambiguity, motivated by technical ownership, and driven by real-world impact

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